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Title: Polychelates of Trivalent Selected Metal Ions of 4f Block With Phenolic Resin and Their Antimicrobial Activities

Authors: Dr.Nileshkumar Madhubhai Baria

Topic: Engineering & Technology

Abstract:

The polymeric ligand (resin) was prepared from 2,4-dihydroxy benzophenone with 1,4-butane diol in presence of polyphosphoric acid as a catalyst at    160°C for 13 hrs.. The poly [(2,4-dihydroxy benzophenone)   1,4-butylene  ] i.e.       H(DHBP-1,4-BD) forms, 1:2 metal:ligand chelates with La(III), Pr(III), Nd(III), Sm(III),Gd(III), Tb(III), and Dy(III). The polymeric ligand and its polychelates were characterized on the basis of elemental analyses, electronic spectra, magnetic susceptibilities, thermogravimetric analysis, NMR and IR results. The molecular weight was determined using number average molecular weight ( ) by the vapour pressure osmometry (VPO) method. All the polychelates are paramagnetic in nature except La(III). The resin and their polychelates were tested for antimicrobial activity against E. coli, B. substilis, and S. aureus (bacteria) and S. cerevisiae (yeast). It is found that the synthesized polychelates can be used as an effective and efficient antibacterial agents.

 

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    COMMENT - 1

  • Dr. AJIT V PANDYA (Viewer) 21st Nov 2015 - 4:32 PM
    antibacterial agents are best known - antibiotics........better if one can find natural / herbal most effective as good as antibiotic...?
    • Nileshkumar Madhubhai Baria (Author) 25th Nov 2015 - 2:00 PM
      Dr.NILESHKUMAR MADHUBHAI BARIA (Author)
      Dear Dr. AJIT V PANDYA (Viewer),
      All the Ln(III) elements are obtained in nature in combined state. after different extraction process it is extracted from it's ore. polychelates prepare from these natural elements . on their antimicrobial behavior used as an antimicrobial agents.

  • COMMENT - 2

  • Amankwa Eric (Viewer) 23rd Nov 2015 - 2:59 PM
    AMANKWA ERIC
    The article seems very good and well presented.
    I guess you mentioned some infrared spectra? please wchich exact optical method did you apply ?
    • Nileshkumar Madhubhai Baria (Author) 25th Nov 2015 - 2:04 PM
      Dr.NILESHKUMAR MADHUBHAI BARIA (Author)
      Dear Amankwa Eric (Viewer) ,
      all mention analytical methods apply for characterization of polychelates . they are screened for tested against mention microorganism by agar diffusion method. on their antimicrobial behaviour used as an antimicroial agents.

  • COMMENT - 3

  • Nileshkumar Madhubhai Baria (Author) 23rd Nov 2015 - 8:12 PM
    Dr. Nileshkumar M Baria ( Authour)
    The results indicate that all the polychelates of lanthanides (III) with the polymeric ligands show good antimicrobial activity compared to free polymeric ligands. It is found that chelation tends to make the ligands act as more potent bactericidal agents than the parent ligands. The increase in activity is due to the formation of a chelate as the positive charge of the metal is partially shared with the donor atoms of the ligands and there is π-electron delocalization over the whole chelate ring.

  • COMMENT - 4

  • Nileshkumar Madhubhai Baria (Author) 23rd Nov 2015 - 8:31 PM
    Dr.NILESHKUMAR MADHUBHAI BARIA (Author)
    All the polychelates of lanthanides (III) with the polymeric ligands show good antimicrobial activity compared to free polymeric ligands. It is found that chelation is more effective for ligand to act as more potent bactericidal agents. The thermal stability of polychelates is less than the polymeric ligand.

  • COMMENT - 5

  • Nileshkumar Madhubhai Baria (Author) 23rd Nov 2015 - 8:51 PM
    Dr.NILESHKUMAR MADHUBHAI BARIA (Author)
    Several studies have proven that its use in combination with antimicrobial compounds incorporated in edible coating results in the increase of bacteria radio sensitivity. geometry of the chelated polymers was confirmed by magnetic susceptibility measurements, UV-Visible spectroscopy and Electron Spin Resonance. The molecular weight of the polymer was determined by gel permeation chromatography (GPC). Thermogravimetric analysis indicated that metal polychelates were more thermally stable than their corresponding ligand. All compounds were screened for their antimicrobial activities against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, (bacteria) and Candida albicans, Microsporum canis, Cryptococcus neoformans (fungi) by agar well diffusion method.On the basis of thermal and antimicrobial behavior, these polymers hold potential applications as thermally resistant antimicrobial and antifouling coating materials as well as antimicrobial packaging materials.

  • COMMENT - 6

  • Nileshkumar Madhubhai Baria (Author) 24th Nov 2015 - 2:04 PM
    Dr.Nileshkumar M Baria ( Author )
    Dear Amankwa Eric (Viewer) ,
    all mention analytical methods apply for characterization of polychelates . they are screened for tested against mention microorganism by agar diffusion method. on their antimicrobial behaviour used as an antimicroial agents.