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Article Number: EC2/2015/131

Authors: UmaDevi Kantipudi1, SR Sheela1, *CD Dayanand1, Nagarjuna Sivaraj2

Topic: Health Science


Aim: To assess whether Serum Leptin and Lactate dehydrogenase levels as an indication of severity in preeclampsia.

Study Design: A prospective case control study, consist of two groups such as group 1 normotensive Pregnants and group 2 as cases with clinically diagnosed preeclampsia

Place and Duration of Study: Department of Obstetrics and Gynaecology, RL Jalappa Hospital and Research Centre and Proteomics laboratory kolar, between January 2013 and July 2014.

Methodology: A total number of 100 pregnant patients were enrolled in the present study. Amongst, normotensive and preeclamptic pregnant women Group1 (n=50) as controls (n=50). Group-2 (n=50) were preeclampsia cases. Five ml of blood samples were collected from each normal pregnant and preeclampsia patients. Leptin levels and lactate dehydrogenase parameters were estimated using ELISA - Micro plate Reader method.  Statistical analysis analysed by using SPSS Software.

Results: The Mean ± SD values of Lactate dehydrogenase IU/L (399.04±113.08) and Leptin ng/ml (9.02±4.65) in normal pregnants and Lactate dehydrogenase IU/L (1296.68±1732.95), Leptin ng/ml (23.32±8.78) in preeclampsia cases were presented. Similarly Mean ± SD values in preeclampsia were presented respectively.

Conclusion: The elevated serum leptin levels in preeclampsia indicate endothelial dysfunction involved in the pathogenesis of preeclampsia. The relationship of serum leptin and Lactate dehydrogenase levels were increased in preeclampsia that is directly proportional to gestational age in last trimester. These biochemical parameters were significantly elevated in severe preeclampsia, mild preeclampsia and compared to normal pregnancy. Identification of high-risk patients with elevated levels of serum lactate dehydrogenase and Leptin necessitate the close monitoring for prompt and correct management which may decrease the complications of disease condition and also facilitate to reduce maternal and fetal morbidity and mortality.


    COMMENT - 1

  • Bhavita Patel (Viewer) 17th Nov 2015 - 11:18 PM
    Hii.....So does it mean that hyperleptinemia and high LDH levels can be used as predictors if complications in preeclamptic women ??/
    what are the normal levels of leptin in non pregnant females ??
    does the high leptin levels causes any complications in preeclampsia ??
    Bhavita Patel

  • COMMENT - 2

  • C.D. Dayanand (Author) 18th Nov 2015 - 6:02 PM
    Dear madam
    thnak you for comment

    In preeclampsia, leptin receptors expressed more in maternal tissues, that relates to the hypermetabolic state and gain in body weight compared to normal pregnants and non pregnants and also maternal tissue destruction released more amount of LDH evident in the study
    this fact needs to be elucidated well in preeclampsia, this is the research gap we explored in this study. is leptin level in normal pregnants
    preeclampsia is a maternal complication rised leptin level

    Please post comment for any further clarification

    prof. Dr C.D. Dayanand

  • COMMENT - 3

  • Dr. AJIT V PANDYA (Viewer) 25th Nov 2015 - 2:02 PM
    Good morning..... From Ajit.....any further development.....

  • COMMENT - 4

  • C.D. Dayanand (Author) 26th Nov 2015 - 12:42 PM
    Dear Viewer Dr Ajit Pandya

    Your interest shown on every domain of research paper is appreciable
    What kind of development expected by you

    Prof Dr.C.D.Dayanand

  • COMMENT - 5

  • PETHURU.D (Viewer) 26th Nov 2015 - 5:11 PM
    Dear Author,

    It is a Good study with nice Analysis of Data. It can be the useful bio marker as mentioned in the conclusion part.
    Are you sure about the study design? It is not case control study. Case control study can not be prospective. Then what is this study design?

  • COMMENT - 6

  • Diana Thamby Ebenezer (Viewer) 26th Nov 2015 - 5:16 PM
    Dear Sir,

    It is a well scientific study. What is your further recommendation based on this study?

  • COMMENT - 7

  • J.Carolin Joe Rosario (Viewer) 27th Nov 2015 - 1:00 PM
    Its a good analytical study.